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May 2019 - Hair and Nail Papers - Journal Club - British Hair and Nail Society

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May 2019 - Hair and Nail Papers

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Here are a few items from journals published in May that I thought were of interest.


Louise Photiou and colleagues in Melborne published an update on the pathogenesis of frontal fibrosing alopecia (FFA) in the Australasian Journal of Dermatology, { (2019) 60, 99–104,}  and state that current evidence suggests that FFA is a unique entity and complex interactions between immune, genetic, hormonal and environmental contributions underlie its pathogenesis. They discuss each of these areas in detail and reviewed the Ovid medline database up to August 2108, listing the published cases and the clinical features. Porrino-Bustamante and colleagues from Spain also provide a cross sectional study of 20 familial cases of FFA from 9 families.  


The Australasian journal also has a case report of alopecia universalis improving with Apremilast in a 52 year old woman with a 30 year history of alopecia universalis that had not responded to several systemic therapies. There was some regrowth on the scalp after 15 weeks.  In the same issue M Kasprzak and colleagues propose the term “Trichoscopy Derived Sinclair Scale” to describe the use of quantitative trichoscopy in place of a visual assessment to grade midline hair density.


The Journal of the American Academy of Dermatology has a 2 CME articles on hair disorders in patients with cancer written by Azael Freites-Martinez et al. The first covers the incidence and clinical presentation of hair disorders including alopecia (transient/persistent) in cancer patients during treatment it discusses the current pathogenic mechanisms underlying various hair disorders in the oncology setting and describes preventive, reactive, and experimental management strategies. It also covers the impact of hair disorders on patients' quality of life; and develop a fundamental understanding of hair disorders in cancer patients. The second article focuses on the hair disorders in cancer survivors. These include persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, endocrine therapy–induced alopecia and hirsutism, postsurgery alopecia and localized hypertrichosis, and persistent stem cell transplantation and targeted therapy-induced alopecia.


In the BJD T. Maruthappu et al show that dominant Arrythomogenic Cardiomyopathy(AC)‐associated loss‐of‐function Desmoplakin mutations can also be linked to curly hair and mild palmoplantar keratoderma and therefore these cutaneous features could provide clinical clues enabling early diagnosis and directed family screening, especially in the subtle early phases of AC.


Finally in JAMA Dermatology Solam Lee and colleagues from Korea present their work establishing the Topography-based Alopecia Areata Severity Tool (TOAST) a prediction model and grading system for stratifying prognosis in alopecia areata.  

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