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  3. All About Alopecia

    @Friends Meeting Room, 6 Mount Street, M2 5NS 11am-3pm
  4. Frontal fibrosing alopecia (FFA) is an increasingly common hair disorder characterised, in most cases, by a specific pattern of hair loss along the frontal hairline. The exact cause of this condition is complex and likely to be related to both genetic and environmental factors (i.e. multifactorial). A recent exciting new study published in the Journal of Investigative Dermatology (November 2017) looked at how some of the genetic factors might contribute to this disease. In particular, this study examined the role of microRNAs (miRNAs) in the development of FFA. miRNAs are relatively newly discovered short non-coding RNA molecules found in humans that bind specifically to messenger RNA, involved in the process of gene expression, ultimately resulting in downregulation of protein expression and affecting aspects of cellular function and turnover. In this study, the researchers compared miRNA expression from blood samples of 10 FFA patients and 10 non-affected controls. They found that 55 miRNAs were upregulated in the blood of patients with FFA while 11 miRNAs were downregulated compared to controls. They also examined miRNA expression patterns in the affected scalps of 7 patients with FFA and compared with 7 non-affected controls. Importantly, they found 9 circulating miRNAs that were more commonly expressed in the scalps of patients with FFA compared with controls. Of these, 4 particular miRNAs were found to be highly linked to the disease. Using new analytical techniques, they discovered that these 4 miRNAs were linked to essential cell signalling, transport and adhesion pathways suggesting possible mechanisms as to how they might contribute to the disease process in FFA. This exciting study helps us to define further the complex interplay of genetic factors that contribute to FFA and, perhaps more importantly, identifies possible targets for therapeutic intervention in the future for this difficult disease. However, like all gene analysis studies, further research is necessary to determine exactly how these miRNAs might contribute to FFA and how they can be targeted in the future.
  5. Frontal fibrosing alopecia (FFA) is an increasingly common hair disorder characterised, in most cases, by a specific pattern of hair loss along the frontal hairline. The exact cause of this condition is complex and likely to be related to both genetic and environmental factors (i.e. multifactorial). A recent exciting new study published in the Journal of Investigative Dermatology (November 2017) looked at how some of the genetic factors might contribute to this disease. In particular, this study examined the role of microRNAs (miRNAs) in the development of FFA. miRNAs are relatively newly discovered short non-coding RNA molecules found in humans that bind specifically to messenger RNA, involved in the process of gene expression, ultimately resulting in downregulation of protein expression and affecting aspects of cellular function and turnover. In this study, the researchers compared miRNA expression from blood samples of 10 FFA patients and 10 non-affected controls. They found that 55 miRNAs were upregulated in the blood of patients with FFA while 11 miRNAs were downregulated compared to controls. They also examined miRNA expression patterns in the affected scalps of 7 patients with FFA and compared with 7 non-affected controls. Importantly, they found 9 circulating miRNAs that were more commonly expressed in the scalps of patients with FFA compared with controls. Of these, 4 particular miRNAs were found to be highly linked to the disease. Using new analytical techniques, they discovered that these 4 miRNAs were linked to essential cell signalling, transport and adhesion pathways suggesting possible mechanisms as to how they might contribute to the disease process in FFA. This exciting study helps us to define further the complex interplay of genetic factors that contribute to FFA and, perhaps more importantly, identifies possible targets for therapeutic intervention in the future for this difficult disease. However, like all gene analysis studies, further research is necessary to determine exactly how these miRNAs might contribute to FFA and how they can be targeted in the future.
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    1st World Congress of Trichoscopy and Symposium All About Hair and NailsDate: 15th - 17th March 2018Venue: Warsaw Marriott Hotel, Al. Jerozolimskie 65/79, WarszawaOrganiser: The International Trichoscopy Society, founded in May 2017Website: http://www.hairnails2018.com/1.2018/en/Invitation__5.html The International Trichoscopy Society was established after the impressive success of trichoscopy, a new diagnostic method, which recently developed into a basic diagnostic tool in dermatological practice. Trichoscopy also evolved into a great research tool in dermatology. The 1st World Congress of Trichoscopy will be combined with the symposium All About Hair and Nails, which will be an excellent setting to discuss the current progress in diagnosing hair, scalp and nail disorders. Worldwide opinion leaders will share with you knowledge about current standards and new therapeutic methods in hair, scalp and nail disorders. The value of cosmetic products as adjuvant products in dermatological practice will be discussed. Pre-congress courses will focus on basic trichoscopy and nail surgery. Young scientists are especially encouraged to present their recent findings and case reports. The ITS is looking forward welcoming you in Warsaw, one of the most modern cities in Europe.
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    98th Annual Meeting of the British Association of Dermatologists AGM of the British Association of DermatologistsDate: 3rd-5th July 2018Venue: EICC Edinburgh, UKOrganiser: British Association of DermatologistsEmail: conference@bad.org.uk Address The Exchange Edinburgh, 150 Morrison St, Edinburgh EH3 8EE Program See draft program now attached. Interested in submitting an abstract for consideration for 98th Annual Meeting, click here Abstract Submission Deadlines: Abstract Submissions - Main Meeting Deadline: by midnight on Monday 8th January 2018 Special Interest Group Submissions The BHNS talks will take place on Thursday 5th July. Deadline: by midnight on Monday 5th February 2018 More information: http://www.bad.org.uk/events/annualmeeting If you have any questions, particularly about accommodation, please contact rose.wilmot@nhs.net Thanks, Rose BNHS Session with Guest speaker talk titles.doc
  8. Update on Nail Disorders Meeting

    Photos from the 'Update on Nail Disorders' Meeting at Cheltenham, 2017
  9. Tissue and circulating microRNA co-expression analysis reveals potential involvement of miRNAs in the pathobiology of frontal fibrosing alopecia (FFA). Tziotzios C, Ainali C, Holmes S et al. JID (2017), doi: 10. 1016/j.jid.2017.06.030 MicroRNAs (miRNAs) are small, non coding RNAs that may impact protean biologic functions. This study sought to characterise miRNAs in FFA and probe disease relevance by undertaking tissue and circulating miRNA co-expression analysis in FFA cases and matched controls. They recruited seven newly diagnosed, treatment-naive FFA cases and 7 matched controls. Temporal scalp skin biopsies were obtained from all cases and controls for microarray analysis. Venous blood samples were also obtained from a separate cohort of 10 biopsy-proven, treatment naive FFA cases and 10 matched controls for circulating miRNA analysis. They constructed a co-expression network of tissue miRNAs by assessing pairwise similarity of miRNAs expressed in each group of cases and controls, calculated using the Pearson correlation coefficient (PCC). The resulting FFA network displayed 2,089 co-expressed miRNAs (nodes) with 3,009 non-duplicate interactions (edges), while for controls there were 2,100 co-expressed miRNAs (nodes) with 2,934 non-duplicate interactions (edges). For the circulating miRNA dataset, 55 miRNAs were upregulated in FFA while 11 miRNAs were downregulated compared to controls. To further evaluate differentially expressed circulating miRNAs, they were mapped within tissue-specific co-expression networks. There were 17 miRNAs common in both networks (cases and controls): 3 of these were specific to controls while 9 were representative of FFA. Of those 9 circulating miRNAs, 4 were found to be highly predictive of disease status: hsa-let-7d-5p, hsa-miR-18a-5p, has-miR-20a-5p, and hsa-miR-19a-3p. Finally, they applied GAGE analysis and found MAPK signalling, endocytosis and focal adhesion pathways to be down regulated and enriched in the networks of co-targeting genes across these 4 miRNAs. The authors concluded that these 4 circulating miRNAs were highly predictive of disease status in FFA but that further studies are required to determine mechanistic relevance. By Nicola Cooke
  10. 27th EADV Congress, Paris

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    The European Academy of Dermatology and Venereology has chosen one of the most beautiful congress cities in Europe, Paris, to host its 27th Annual Congress in 2018. All abstracts should be submitted online in English through the official Congress website. For information and questions, please refer to the Call for Abstracts page or contact EADV at abstracts@eadvcongress.org. The deadline for abstract submissions is below: Online submission of abstracts opens: 27 November 2017 Abstract submission deadline: 13 March 2018 Abstract evaluation deadline: 22 May 2018 To register: https://eadvparis2018.org/registration/
  11. Alopecia UK's Big Weekend!!

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    [Ticket Sales close: Sunday 17th September 2017]Come along to Alopecia UK's fourth 'Big Weekend' where we will have a series of events for those affected by alopecia. This year's host city is Birmingham. We have four individual events that make up the weekend and you can choose to attend either one, two, three or all four. Below you can find a brief overview of the weekend... Weekend overview: Friday EVENING: Our Exhibition Hall will be open with reception drinks and canapes. A great opportunity to meet others with alopecia in a relaxed setting (7pm - 9:30pm). Suitable for adults and older teens. We advise children to save themselves for the Saturday! Although we will do our best to put families in touch for the Friday night in case they want to go bowling or something similar. Saturday DAYTIME: A adult conference filled with talks, workshops, exhibitors and demonstrations. The focus here is very much on information sharing (9:30am - 5:30pm). We will also facilitate a Children and Teens specific event within the conference with games, a crafty area, a chill out area, and some fun workshops and speakers as well (10:30am - 4:30pm). More details will be announced over the coming months. Saturday NIGHT TIME: A great opportunity to chat with others over a buffet dinner followed by some fun and dancing! As always we will have a blue theme in honour of it being Alopecia Awareness Month so do dig out your blue dresses, suits, shirts, tops, fancy dress (?!) – anything goes! (7pm - midnight). Sunday DAYTIME: Our Sunday event is typically about doing something awareness related. This year we will be facilitating a photoshoot and video making in order to create lots of content that Alopecia UK can use for awareness both online and in Charity Resources. So we're after some models* please! This is new for 2017 and still needs developed but we would appreciate those who are comfortable being photographed getting involved. It will be a nice relaxed day and I'm sure we'll incorporate a bit of fun, with perhaps a walk through Birmingham to the infamous 'Bullring' for some extra photos (10:30am - 3pm). http://www.alopeciaonline.org.uk/big_weekend_conference_line_up.asp
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    The Annual UK Dermatology Course for Consultants Dates: 17th – 18th November 2017 Venue: Hilton Metropole Hotel, London Organisers: Conference & Event Services from the BAD Email: conference@bad.org.uk Registration for this event has now closed.
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    An Education course over 2 days based in Glasgow at the Crown Plaza Hotel. 7 CPD Credits have been approved for this event. British Hair & Nail Society - Hair Educational MeetingDate: 16th - 17th March 2018Venue: Crowne Plaza Hotel, GlasgowOrganiser: Conference & Event Services from the BADEmail: conference@bad.org.uk Address Crowne Plaza Hotel Congress Road Glasgow G3 8QT Program Programme – Friday 16th March 09:30 - 10:25 Registration and Coffee 10:25 - 10:30 Welcome - Dr Susan Holmes, Glasgow 10:30 - 11:05 Clinical Assessment of Hair Loss - Dr Manjit Kaur, Birmingham 11:05 - 11:40 Lichenoid Alopecias - Dr Matt Harries, Manchester 11:40 - 12:15 Alopecia Areata - Dr Abby Macbeth, Norwich 12:15 - 12:50 Telogen Effluvium - Dr Jen Jones, London 12:50 - 14:00 Lunch 14:00 - 14:35 Male and Female Pattern Hair Loss - Dr Paul Farrant, Brighton 14:35 - 15:10 Cosmetic Management of Alopecia - Dr Vicky Joliffe, London 15:10 - 15:45 Hair Transplantation - Dr Nilofer Farjo, Manchester 15:45 - 16:10 Coffee 16:10 - 16:45 The Neutrophilic Alopecias - Dr Anita Takwale, Cheltenham 16:45 - 17:20 New Developments in Understanding Alopecia Pathogenesis - Dr Christos Tziotzios, London 17:20 Closing remarks - Dr Susan Holmes, Glasgow Programme – Saturday 17th March 09:00 - 09:15 Bus to Elizabeth University Hospital 09:30 - 10:30 Clinical Cases 10:30 - 11:00 Coffee 11:00 - 12:00 Discussion of cases 12:00 End of meeting To apply: https://www.eventsforce.net/bad/frontend/reg/thome.csp?pageID=70973&eventID=242&eventID=242 If you have any questions, particularly about accommodation, please contact rose.wilmot@nhs.net Thanks, Rose
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    The 18th Annual Meeting of the European Hair Research Society will be in Bologna next year. The abstract submission deadline is the 30th March 2018. For more information about the event and how to register please visit their website: http://www.ehrs2018.org/ The BHNS is now accepting applications for a travel fellowship to attend this event in Italy. The application form for this is attached. Please email rose.wilmot@nhs.net to apply or if you need more information. EHRS travel fellowship BHNS 2.docx
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